Antioxidant and Ameliorative Effects of Basella alba L. On Letrozole-Induced Polycystic Ovarian Syndrome in Rats

Basella alba L. (BA) is utilized in Nigeria to manage Polycystic Ovarian Syndrome (PCOS), according an ethnobotanical study. However, this claim has not been supported by any scientific data. This study investigated the effect of methanol leaf extract plant alleviating polycystic ovary conditions rats. The BA was subjected a brine shrimp lethality assay. Total Phenolic Content (TPC), Flavonoid (TFC), and DPPH assay were used measure antioxidant activity. To induce PCOS thirty female Wistar rats (180-200 g), letrozole (1 mg/kg) used. For 15 days, (100 mg/kg body weight) Clomiphene citrate weight), standard medication, given. Microscopically, ovaries underwent histopathological investigation. ELISA assess luteinizing hormone (LH), follicle-stimulating (FSH), estradiol levels. One-way ANOVA analyze data, P < 0.05 set as threshold for Dunnett's Multiple Comparison Test. LC50 value 17.29±0.15 μg/mL. radical scavenging activity ethyl acetate fraction highest. When animals given BA, ovarian stroma normal granular cells leutinized. level increased but LH significantly different between BA-treated group (0.23±0.03 mIU/mL) untreated (0.23±0.01 mIU/mL). displayed ameliorative effects on support use management PCOS.